PODXL and rheumatoid arthritis: Ω3FA has been demonstrated to play a role in this cytokine storm by being a substrate of plasma and synovial fluid specialized pro-resolving mediators (SPMs) such as the recombinant bivalent fusion protein (RvEs), protectin D1 or neuroprotectin D1 (PD1), protectin DX (PDX), and the pro-resolving lipid mediator maresin 1 (MaR1), which reduce circulating inflammatory cytokines, thereby reducing inflammatory-mediated diseases such as rheumatoid arthritis (RA) disease activity [88,89].