ADIPOQ and Insulin resistance: We also showed that the supplementation with GSPE to dams exclusively during lactation increased energy expenditure and the circulating adiponectin levels of their offspring fed either a standard show (STD) or an obesogenic cafeteria diet (CAF), which resembles the MetS occurring in humans [24]; this intervention induced an adiponectin resistance-like phenotype accompanied by insulin resistance in these progeny [25].