A low adiponectin/leptin ratio (<1), which is characterized by a lower secretion of adiponectin in relation to leptin, has been described as a marker of dysfunctional adipose tissue and it is associated with cardiometabolic risk in humans, reflecting the obesity-related disturbances in the adipose tissue [72,73]. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.