Although a chronic imbalance of pro-inflammatory mediators (hs-CRP, IL-1β, IL-6, TNF-α) and anti-inflammatory markers (IL-4 and IL-10) has been reported in obesity, the role of each inflammatory mediator is not completely known and needs to be investigated in further analysis, and the cellular function of these cytokines should be defined in the physiopathology of excess white adipose tissue and obesity [45,47]. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.