As shown in Figure 3, genetically predicted levels of PTH were associated with the risk of IBS (p = 0.012, Beta = −0.188) while IBS was not the risk factor of Vit-D (p = 0.898, Beta = −0.001) and calcium (p = 0.432, Beta = −0.006) using the IVW method. This evidence concerns the gene PTH and irritable bowel syndrome.