This extract, which increases the level of AMPKα2, alleviates abdominal obesity and insulin resistance in C57BL/6J mice by increasing the mRNA levels of carnitine palmitoyltransferase 1 (CPT-1), medium-chain acyl-coenzyme A dehydrogenase (MCAD) [79]. The gene discussed is PRKAA2; the disease is Abdominal obesity.