ARFGEF1 and neoplasm: MiR-27b overexpression inhibited tumor growth, cell adhesion, and invasion by modulating ARFGEF1 and paxillin/c-Src axis, in HCT116 cells, and suppressed proliferation and migration in cancer stem cells by downregulating phospho-PI3K p110α and phospho-Akt expression [64,65].