The expression of p-ERK and p-p38 proteins was not affected by forskolin or SIP treatment, as seen in Figure 7A. The protein expression level of p-JNK was 1.46 times higher in forskolin-stimulated melanoma cells than in the control group, whereas SIP treatment reduced the amount of p-JNK by 30.9% at doses of 1 mg/mL (Figure 7B). Here, MAPK8 is linked to melanoma.