Ischemic placenta releases anti-angiogenic factors (soluble fms-like tyrosine kinase-1, sFlt-1) and decreases placental pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and placental growth factor (PlGF), leading to angiogenic imbalance and endothelial dysfunction [33,34,35]. The gene discussed is PGF; the disease is endothelial dysfunction.