As a consequence, the excessive amount of omega-6 has shown to increase the synthesis of thromboxane A2, leukotriene B4, interleukin-1ß (IL-1ß), interleukin-6 and tumor necrosis factor (TNF), resulting in the development of common chronic inflammatory pathologies such as cardiovascular disease, cancer, obesity, and autoimmune diseases [104]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.