Danggui buxue decoction (DBD) could affect lipid metabolism in the early stage of AS in diabetic Goto-Kakizaki (GK) rats by significantly reducing homeostasis model assessment of insulin resistance (HOMA-IR), the levels of TG, TC and LDL-C in serum, and the expression of the lipogenic genes monocyte chemotactic protein 1 (MCP-1), Fas, intercellular adhesion molecule 1 (ICAM1) and Cd36 in aorta, as well as significantly increasing the mRNA expression of Scd1 in aorta. Here, CCL2 is linked to Insulin resistance.