The expert panel gathered by the International Society of Renal Nutrition and Metabolism proposed the following criteria of PEW: reduced overall body (or fat) mass, reduced muscle mass or the presence of sarcopenia, the reduced dietary intake of energy or protein, and low levels of the following serum markers: albumin, cholesterol, and transthyretin (previously known as prealbumin) [4]. The gene discussed is TTR; the disease is sarcopenia.