TNF and obstructive sleep apnea syndrome: Specifically, the inflammatory profile of OSA is characterized by the recruitment of macrophages and the presence of circulating inflammatory biomarkers, such as C-Reactive Protein (CRP), chemokines and cytokines such as Interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), nuclear factor kappa B (NFK-B), as well as adhesions molecules such as selectins, intracellular adhesion molecule-1 (ICAM-1), and vascular intracellular adhesion molecule-1 (VCAM-1) [116,117].