NR1H4 and steatosis: Rodrigues et al. [32] reported that miR21-knock-out mice—as compared to wild-type mice—who were fed a Western-type diet supplemented with obeticholic acid showed minimal steatosis, inflammation and lipo-apoptosis, which was most likely caused by an upregulation of PPARA and Farnesoid-X-Receptor (FXR) activation.