Pancreatic cancer cells (PANC-1, SW1990, and AsPC-1) expressed higher levels of TGF-β1 compared to normal pancreatic ductal epithelial cells, and inhibition of TGFBR1 in endothelial cells blocked the inhibitory effect of BBR on trans-endothelial migration of AsPC-1 cells [124]. Here, TGFBR1 is linked to familial pancreatic carcinoma.