MIA-PaCa-2 cells possess a R248W TP53 gain-of-function mutation resulting in expression of a p53 protein with a mutated DNA binding domain effectively blocking the tumour suppressive properties of p53 [120]; transfecting MIA-PaCa-2 cells to express wildtype p53 caused a three-fold reduction in the IC50 of BBR [121]. This evidence concerns the gene TP53 and neoplasm.