While SHIP is often considered as reversing signals initiated from PI3K phosphorylation, such as the well-known tumor promoter phosphatase and tensin homolog protein (PTEN) [8], the situation is more complex, with significant evidence pointing to SHIP1/2 facilitating tumor cell survival [9,10,11,12,13,14,15]. The gene discussed is PIK3CA; the disease is neoplasm.