Despite observations that trigonelline shows in vitro anticarcinogenic potential through induced apoptosis, suppression of nuclear factor erythroid 2-related factor 2 (Nrf2) activity, induction of cytoprotective genes [54], as well as inhibition of reactive oxygen species (ROS)-induced proliferation of invasive cells [55], a correlation has also been found in the development of breast cancer. Here, NFE2L2 is linked to breast cancer.