Thus, vitamin A may promote the differentiation of T cells, towards the immunosuppressant Th2 and Treg phenotypes, regulating relevant transcription factors, by inhibiting the generation of cytokines, such as IL-12, TNF-alpha and NO, and resulting in EAE suppression and proliferation of immune reactive cells, whilst its deficiency may account for MS pathogenesis risk [85]. Here, TNF is linked to myeloid sarcoma.