TNFSF10 and acute leukemia: In a recent study, Wu et al. reported that rocaglamide breaks the TRAIL-induced resistance in vitro and in vivo in multiple myeloma and acute leukemia by inhibiting c-FLIP (main factor in TRAIL therapy resistance) expression and thereby increasing the effects of camptothecin, which shows that combined use of rocaglamide can be a suitable therapeutic option [176].