STAT3 and Familial prostate cancer: Moreover, lycorine extracted from Amaryllidaceae plants inhibited the growth, proliferation, migration, and invasion of multiple prostate cancer cells in vitro (LNCaP, PC-3M, DU145, and 22 RV1) and in vivo (PC-3M xenograft) model by abrogating p-STAT3 expression, reversed EMT via STAT3-mediated twist decrease, and inhibited EGF-induced JAK/STAT signaling [164].