Similarly, crocin isolated from saffron has been shown to produce autophagic apoptosis and inhibit the growth and proliferation of human hepatic cancer (HCCLM3 and HepG2) cells via upregulation of LC3-II and constraining the functional activities of key proteins involved in Akt/mTOR signaling pathway such as p-Akt, p-mTOR, and p-p70S6K [145]. Here, AKT1 is linked to liver cancer.