FOXP3 and neoplasm: Similarly, Radix glycyrrhizae polysaccharides have been shown to downregulate the number of Treg cells in the microenvironment of H22 tumor xenograft mice by decreasing the expression of Foxp3 in Treg cells while upregulating the Th1/Th2 ratio in serum; as a result, inhibiting tumor growth [64].