AKT1 and breast cancer: In another study, flavokawain B induced apoptosis and inhibited the proliferation of breast cancer (MCF-7 and MDA-MB231) cells by upregulating various kinases such as p-Akt, p-JNK, p-CREB, p-p53, and p-WNK1 and downregulating Nf-kβ, COX2, MMP-9, GLUT1, and VEGFA [115].