PGP and breast carcinoma: Moreover, glabridin, a flavonoid, has been shown to reverse the P-gp mediated resistance to the conventional chemotherapeutic drugs (Doxorubicin and paclitaxel) in P-gp overexpressing breast cancer (MDA-MB-231/MDR1 and MCF-7/ADR) cell lines by suppressing P-gp and downregulating the functional activity of P-gp- ATPase and thereby reversing the multidrug resistance [94].