For example, diarylheptanoid hirsutenone potentiates the TRAIL-induced apoptotic activity in ovarian cancer (OVCAR-3 and SKOV-3) cells by enhancing the activation of caspase-8 and BID dependent signaling pathways, which further activates caspase-3/-9, exhibiting the significance of hirsutenone in combination with TRAIL treatment [117]. The gene discussed is TNFSF10; the disease is ovarian cancer.