Similarly, a combination of capsaicin and docetaxel has been shown to have higher cytotoxicity against prostate cancer (LNCaP and PC3) cell lines and tumor xenograft in mice by inhibiting the growth and proliferation via reducing Akt, mTOR, and S6 phosphorylation while increasing (AMPK) phosphorylation [81]. This evidence concerns the gene AKT1 and neoplasm.