JTB dysregulation in MCF7 cells was associated with downregulation of other proteins that might be associated with pro-apoptotic and anti-tumorigenic effects, such as calcium-calmodulin N-terminal domain 1(CALM1), downregulated here in overexpressed JTB condition, which induces apoptosis in MM cells [60] or ESCC [66], and SOD1, downregulated in both overexpressed and downregulated JTB condition [61]. The gene discussed is SOD1; the disease is esophageal squamous cell carcinoma.