ENO2 and cancer: HALLMARK_FATTY_ACID_METABOLISM was found to be significantly upregulated in overexpressed JTB condition in correlation with the overexpression of ENO2, a glycolysis-related enzyme that contributes to the increased fatty acid production [125] and HSP90AA1 that may activate the MTORC1 signaling pathway [107], which is upregulated in multiple cancer types, including BC [126], leading to cell growth and tumor proliferation and playing a significant role in endocrine resistance in BC [127].