JTB overexpression was here associated with an alteration in the expression of proteins that have been functionally linked to selective degradation of target misfolded proteins by HALLMARK_UNFOLDED_PROTEIN_RESPONSE (UPR) (RPS14, RPL6, TUBB2A, and PRKCSH) and chaperone-mediated autophagy (CMA) (LAMP2, HSP90AA1, and EEF1A1), promoting proliferation, migration and survival cancer cells in stress condition. The gene discussed is PRKCSH; the disease is cancer.