The overexpressed heat shock protein family D (HSP60) member 1 (HSPD1) might repress E-cadherin expression, promotes cancer cell invasion, migration [18], and mitochondrial dysfunction, assists protein folding, tracking and degradation, enhances tumor cells survival, while its downregulation induces tumor cell apoptosis in BC cells and cell lines [143]. The gene discussed is CDH1; the disease is cancer.