We focused on the participation of actin filaments and microtubules-related proteins in promoting EMT and their influence on cancer metastasis, such as TMSB10, TPM3, IQGAP2, ACTC1, ACTG1, ACTN4, TUBA4A, TUBB, TUBA1A, TUBB2A, POTEKP/ACTBL3, and EEF1A1. This evidence concerns the gene ACTC1 and cancer.