Playing an important role in tumor metabolism, phosphoglycerate kinase 1 (PGK1), upregulated in JTB downregulated condition in this experiment, under hypoxic conditions, promotes glycolysis and increases stem-cell like abilities and the EMT in oral squamous cell carcinoma (OSCC) cells through the AKT signaling pathway [108]. The gene discussed is PGK1; the disease is neoplasm.