Proteins involved in cytoskeletal dynamics that promote EMT and influence BC metastasis are: TMSB10, TPM3, IQGAP2, ACTC1, ACTG1, ACTN4, TUBA4A, TUBB, TUBA1A, TUBB2A, POTEKP/ACTBL3, and EEF1A1, listed in Table 3 and Table 4. The gene discussed is ACTC1; the disease is breast cancer.