AKT1 and neoplasm: Another typical example is sanguinarine, a plant-derived cancer prevention and treatment alkaloid; it impedes tumor metastasis and development by disrupting a wide range of cell signaling pathways, and molecular targets such as B-cell lymphoma-2 (BCL-2), mitogen-activated protein kinases (MAPKs), protein kinase B (Akt protein), nuclear factor kappa B (NF-κB), reactive oxygen species (ROS), and microRNAs (miRNAs) [31].