The results reveal a significant decrease of p-mTOR/mTOR protein expression levels at 100 μM and a significant decrease of p-Akt/Akt protein expression levels at 50 and 100 μM of RD2 treatment in NSCLC cells (A549 and H23) compared with the untreated control. The gene discussed is MTOR; the disease is non-small cell lung carcinoma.