While Akt and mTOR fluorescence intensity were not notably changed in RD2 and RD3 in NSCLC (A549 and H23), RD2 induced a dramatic decrease of the p-mTOR signal in NSCLC cells (A549 and H23) at 50–100 μM, while RD3 only minimally affected the intensity of p-mTOR signal (Figure 5c, Figure 6c, Figure 7c and Figure 8c). Here, RD3 is linked to non-small cell lung carcinoma.