As resveratrol has a relatively simple structure and contains several functional groups that could be modified including benzene diol groups, hydroxyphenyl, and aromatic rings, we synthesized the new analogues of resveratrol derivatives and tested for anti-cancer activity and their effect in targeting Akt/mTOR signaling pathway as well as the effect of chemical structure modification on such a compound action. The gene discussed is MTOR; the disease is cancer.