To investigate the anti-cancer potentials of resveratrol derivatives RD1, RD2, RD3, RD4, and RD5 on lung cancer cells, we determined the cytotoxic profile of resveratrol derivatives (RD1-RD5) and resveratrol in several lines of NSCLC cells namely A549, H23, and H460 cells. This evidence concerns the gene TUB and lung carcinoma.