WT1 and hematologic disorder: However, up until now, WT1 displays a controversial and complex function in hematological malignancies, for example, in the HL-60 cell line, the elimination of WT1 by RNA interference (RNAi) or antisense oligonucleotide prevented cell proliferation and cycle progression in Watanabe’s study [13]; however, in Yao’s study, the same elimination of WT1 did not affect cell viability and even promoted cell growth [14].