To investigate the effect of resveratrol on the expression of autophagy-related markers (p62, Beclin1, and LC3) in oral cancer cells, proteins extracted from Ca9-22 cell cultures were treated with various non-cytotoxic concentrations (2–100 μM) of resveratrol and for various time periods (0, 4, 8, 12, 24, 48, and 72 h) that were quantified using immunoblot analysis. This evidence concerns the gene BECN1 and lip and oral cavity carcinoma.