The expression of urate reabsorption proteins (URAT1 and GLUT9) was reduced and secretion proteins (ABCG2, OAT1, and OAT3) were increased in the kidneys of hyperuricemia mice after MOL-FP treatment, indicating that MOL-FP had an inhibitory effect on UA reabsorption and facilitated excretion in hyperuricemia mice. Here, SLC22A8 is linked to hyperuricemia.