In an inflammatory-induced osteoporosis model of experimental rats, oral administration of 20 mg/kg cordycepin showed anti-inflammatory activity and limited bone loss, which in turn decreased the levels of CTX, maleic dialdehyde, myeloperoxidase, IL-1β, and TNF-α in the serum and increased the level of OC [35]. The gene discussed is IL1B; the disease is osteoporosis.