MDM2 and neoplasm: Among those are MDM2, DCAF15, DCAF16, RNF4, RNF114, FEM1B, KEAP1, AhR, cIAP1 and XIAP, which pose several distinct advantages including specificity for tissue, tumor, cell type or cell state, and synergistic tumoricidial effects through activation of pro-apoptotic cell cycle regulatory proteins [54].