Here, silenced miR-210, an essential microRNA for cancer survival in hypoxic niches, derepressed glycerol-3-phosphate dehydrogenase 1-like enzyme (GPD1L), a hypoxia-associated protein, decreased HIF-1α, and triggered apoptotic cell death of diseased cells (MDA-MB-231) only under hypoxic conditions that are critical to the metastatic and invasive characteristics of cancer. The gene discussed is HIF1A; the disease is cancer.