According to TP53 mutation status, almost two times more frequent methylation of MT1E was identified in TP53-mut than in TP53-wt BC cases (58% vs. 32%; p = 0.024), whereas methylation frequencies of PRKCB and RUNX3 were significantly higher in the TP53-wt subgroup (92% vs. 61%, p < 0.001, and 49% vs. 23%, p = 0.021, respectively; Figure 3C). The gene discussed is RUNX3; the disease is breast cancer.