Therefore, this longitudinal study was aimed at exploring the role of urinary cytokines and their relationship with the kidney stress biomarkers neutrophil gelatinase-associated lipocalin (NGAL), the tissue inhibitor of metalloproteinases-2 (TIMP-2) and the insulin-like growth factor binding protein 7 (IGFBP7) in a cohort of patients with severe COVID-19 and subclinical AKI. This evidence concerns the gene TIMP2 and COVID-19.