The study findings suggested that TGFBR2 (a pro-fibrotic factor) might be involved in the mechanism by which the miR−122−5p mimic promotes renal fibrosis and FOXO3 (an anti-fibrotic factor) might be involved in the mechanism by which the miR−122−5p inhibitor suppresses renal fibrosis. This evidence concerns the gene FOXO3 and renal fibrosis.