Thus, considering our recent and novel results in mice demonstrating the protective role of CCN2 in aneurysm development after systemic angiotensin II infusion, and aiming to further decrypt the role of CCN2 in human aneurysms, in this study we wanted to evaluate the potential association between functional SNPs in the gene encoding CCN2 and susceptibility to aortic aneurysm in patients. The gene discussed is AGT; the disease is aortic aneurysm.