CCN2 and systemic sclerosis: However, although the association between CCN2 SNPs and other pathologies such as hepatic fibrosis [15], colon carcinoma [16], diabetic nephropathy [17], pulmonary fibrosis [18], systemic sclerosis [19] and in-stent restenosis [20] has been established, the potential association between CCN2 SNPs and aortic aneurysm development still remains unexplored.