Previous studies have described the association between SNPs in genes encoding cytokines (IL-6 and TNF-α) and several extracellular matrix related-proteins (matrix metalloproteinases, tissue inhibitors of metalloproteinases, TGF-β, elastin and type III procollagen) and aortic aneurysm susceptibility [13,14]. The gene discussed is TGFB1; the disease is aortic aneurysm.