This negative impact of FXRα on steroid synthesis is mainly due to the regulation of Shp (small heterodimer partner; NR0B2) [6] and Dax-1 (dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene-1; NR0B1) expressions [7], two well-known negative regulators of steroidogenesis. Here, NR0B2 is linked to chronic primary adrenal insufficiency.