TIA1 and tauopathy: In tauopathy, somatodendritic Tau co-localizes with TIA1 (TIA1 Cytotoxic Granule Associated RNA Binding Protein, also known as T-Cell-Restricted Intracellular Antigen-1), a RBP that regulates alternative pre-RNA splicing and mRNA translation by binding to uridine-rich (U-rich) RNA sequences [137] and increases the formation of stress granules (SGs).