The authors, therefore, suggest a role for Tau as an upstream regulator of the PI3K/AKT pathway: Akt activity may be necessary for Tau-dependent cell migration, while upstream PI3K activity may be involved in the control of cell growth and survival, indicating that Tau can contribute to tumor progression, possibly through the regulation of cell growth and/or invasion [106]. The gene discussed is AKT1; the disease is neoplasm.