ESR2 and neoplasm: After ERβ silencing we observed that in addition to a significant reduction of ERβ also PTEN, a tumor suppressor which can be modulated by ERβ [16], was reduced, while N-cadherin, vimentin, SNAIL, and Zeb-1 increased after acidic treatment, justifying the phenotype drift to a mesenchymal state (Figure 3, panel A).