In agreement, the Chinese Glioma Genome Atlas (CGGA) database reveals high TRPML2 expression in high-grade GBM, which correlates with shorter OS and worse prognosis, whereas favorable DFS is associated with lower levels of TRPML2; moreover, high TRPML2 levels are associated with 1p/19q non-codeletion and IDH-wild type status [21]. Here, MCOLN2 is linked to central nervous system cancer.