In the present study, we analysed the contribution of two common SAMM50 variants (rs3827385 and rs3761472) as risk factors for HCC in a large cohort of patients with alcohol-associated cirrhosis, with alcoholic HCC and appropriate control cohorts of healthy subjects, subjects with alcohol abuse but an absence of significant liver disease and patients with HCC due to viral hepatitis. This evidence concerns the gene SAMM50 and alcohol abuse.