Next, we performed a univariate analysis of several potential factors associated with the occurrence of HCC (Table 3), which showed that, as expected, age, male sex, diabetes, presence of a PNPLA3 148M allele and presence of a SAMM50 rs3827385 minor allele or a SAMM50 rs3761472 minor allele were associated with the presence of HCC. This evidence concerns the gene PNPLA3 and diabetes mellitus.