In summary, in a large cohort of Caucasian patients with alcoholic HCC, alcohol-associated cirrhosis and different controls, we did not find that genetic variation of the two SAMM50 polymorphisms rs3827385 and rs3761472 previously reported as independent risk factors for HCC in NAFLD conferred an increased risk for HCC in addition to the presence of the PNPLA3 148M variant in patients with cirrhosis related to alcohol abuse. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.