Although there was no prognostic role of BMI1, Sp1, or ZEB1 in the overall survival of NSCLC subjects with a combination of the LUAD and LUSC datasets (Figure S1), the subjects with high expression of a 3-gene signature consisted of BMI1, Sp1, and ZEB1 displayed a significantly shorter overall survival in the NSCLC dataset of TCGA (Figure 6D). Here, ZEB1 is linked to non-small cell lung carcinoma.