In NSCLC, miR-145-5p has been shown to target the c-Jun N-terminal kinase (JNK) signaling pathway mediated by Mitogen-activated protein kinase kinase kinase 1 (MAP3K1), leading to the inhibition of epithelial–mesenchymal transition (EMT) [21]. The gene discussed is MAP3K1; the disease is non-small cell lung carcinoma.