BMI1 and cancer: In addition, we increased miR-145-5p in A549-BS1 cells with BMI1 overexpression by delivering miR-145-5p mimic oligos and found that the proliferation and migratory capabilities of NSCLC cells were inhibited (Figure 4D,E), indicating that miR-145-5p could suppress the BMI1-induced proliferation and metastatic potentials of NSCLC cells, suggesting that miR-145-5p RNA drugs have the potential to be developed as anti-cancer drugs in lung cancer patients with high level of BMI1 expression.