Several findings have emerged: (1) COVID-19 patients had significantly lower cholesterol levels with higher plasma cytokine and oxidative stress levels compared to the control patients at the time of hospital admission; (2) high LPO levels were independently associated with TC and proinflammatory cytokines (IL-1RA, IL-17, and IL-7); (3) lipid profiles rapidly recovered among survivors after hospital discharge, but those with previous high LPO at hospital admission showed an atherogenic lipid profile during long-term follow-up. The gene discussed is IL17A; the disease is COVID-19.