STAT3 and cancer: Accordingly, cancer-derived exosomes enhance the transdifferentiation of CAFs via TGF-β1, Gm26809, miRNA, long non-coding RNA (lncRNA) transport and activation of TGF-β, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), signal transducers and activators of transcription 3 (STAT3), and mitogen-activated protein kinase (MAPK) signaling cascades [76,77].