MAPK8 and Insulin resistance: According to previous studies, the anti-inflammatory and anti-diabetic effects of MGF by inhibiting IRAK1 phosphorylation in NF-κB and MAPK pathways [12], tumor growth and inflammatory responses-related pathways [14], inhibition of JNK activation that can cause liver lipid deposition and insulin resistance [15], and renal fibrosis inhibition via PTEN/PI3K/AKT pathway have been reported [16].