To explore whether the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and phosphoinositide 3-kinase (PI-3K) signaling pathway were involved in the pathogenesis of endometriosis, endometriotic cells were treated with 10 μM wortmannin, a selective and irreversible PI3K inhibitor, or CAPE (caffeic acid phenethyl ester), an antioxidant inhibiting NFκB activation. The gene discussed is NFKB1; the disease is endometriosis.