In gastric cancer, overexpression of OPNb strongly induces cell survival by regulating Bcl-2 family proteins and CD44v expression, while OPNc most significantly promotes cell migration and invasion by increasing the secretion of matrix metalloproteinase-2, urokinase-type plasminogen activator, and interleukin-8 [47]. Here, CXCL8 is linked to gastric cancer.