Our previous study demonstrated that iNKT cells derived from Yeti mice are superior to iNKT cells derived from WT mice in inducing the activation of IL22-producing ILC3s during DSS-mediated colitis, and such an effect of Yeti iNKT cells closely correlated with their capacity to produce increased amounts of IL2, IL4, and IL9 [9]. The gene discussed is IL4; the disease is colitis.