LAV-BPIFB4 gene therapy transduction promotes reparative vascularization and reperfusion in a murine model of peripheral ischemia [17], halts the progression of atherosclerosis and inflammation in ApoE knockout mice [19], rescues diabetic cardiomyopathy in obese mice with type 2 diabetes [20], improved frailty indices in aging mice [21], prevents neuropathological phenotypes in HD models [22] and rejuvenates the immune system and vasculature in aged mice [23]. Here, BPIFB4 is linked to Huntington disease.