GH ameliorated muscle regeneration and myogenesis by decreasing the mRNA expression of negative regulators of skeletal muscle mass (Atrogin-1, Murf-1, Myostatin, and Soc2) while increasing the mRNA expression of promyogenic factors (MyoD, Myogenin, Pax-7, and IGF-I) in CKD mice (Figure 5D–G). Here, SHOC2 is linked to chronic kidney disease.