On the other hand, the C-terminus of PTX-3 (which contains a homologous domain similar to other pentraxin family members such as CRP) interacts with CD44 (a type I glycoprotein located on the surface of lymphocytes, neutrophils, macrophages), proving high affinity for this receptor and activates NF-ƙB signaling pathways in breast cancer cells leading to metastasis [48]. This evidence concerns the gene CRP and breast cancer.