Interestingly, Papila et al. found that PTX-3 had the highest specificity and sensitivity in the cancer group, PTX-3 and PCT were significantly increased in colon carcinoma compared to breast neoplasia and that only PTX-3 was positively correlated with both IL-6 and NF-ƙB, suggesting that PTX-3 could be used as an independent prognostic tool for colorectal cancer [97]. This evidence concerns the gene PTX3 and colorectal cancer.