PTX-3 is associated with many non-malignant conditions (e.g., asthma, hepatic cirrhosis, atherosclerosis, rheumatoid arthritis, systemic lupus erythematosus, sepsis, acute kidney injury, chronic kidney disease, stroke), but also it is overexpressed in various types of tumors (e.g., prostate/breast/lung/hepatic cancer, glioma) [31]. The gene discussed is PTX3; the disease is central nervous system cancer.