These results underline the dual role of PTX-3 in tumor progression as its overexpression can be correlated with poor prognosis in individuals with gastric cancer, pancreatic cancer, breast cancer, glioma, and lung cancer, but its down-regulated expression can be found in esophageal cancer and melanoma [40,41,42,43,44,45]. The gene discussed is PTX3; the disease is central nervous system cancer.