PTX3 and cervical carcinoma: In their clinical study, Berggrund and colleagues found a signature of 11 proteins (also including five proteins that have been previously associated separately with cervical cancer, such as PTX-3, IL-27, SIR2, proto-oncogene tyrosine kinase (SRC), and eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1)) with 0.96 sensitivity and 1.0 specificity, capable of distinguishing cases and controls [78].