Rybarczyk et al. revealed that TRPM7 deficiency decreased the secretion of heat-shock protein 90α (Hsp90α), urokinase plasminogen activator (uPA), and pro-MMP-2, indicating TRPM7 affects the progression of pancreatic ductal adenocarcinoma (PDAC) by regulating the Hsp90α/uPA/MMP-2 proteolytic axis [71]. Here, MMP2 is linked to pancreatic ductal adenocarcinoma.