Additionally, fundamental research into mitochondrial dysfunction in other Mendelian EC diseases closely related to PXE, such as PXE-like syndrome with multiple coagulation factor deficiency (OMIM #610842), GACI, and arterial calcification due to deficiency of CD73 (ACDC; OMIM #211800) is highly warranted. The gene discussed is NT5E; the disease is Pseudoxanthoma elasticum.