SOD2 and pseudoxanthoma elasticum (inherited or acquired): In this regard, an older study from Zarbock et al. showed that common single-nucleotide polymorphisms in the antioxidant genes SOD2, glutathione peroxidase 1 (GPX1), and catalase (CAT) were significantly associated with a younger age of onset of PXE disease, thus highlighting the potential link between redox homeostasis and the development of PXE-related clinical signs and symptoms [43].