NT5E and body skin hyperlaxity due to vitamin K-dependent coagulation factor deficiency: Additionally, fundamental research into mitochondrial dysfunction in other Mendelian EC diseases closely related to PXE, such as PXE-like syndrome with multiple coagulation factor deficiency (OMIM #610842), GACI, and arterial calcification due to deficiency of CD73 (ACDC; OMIM #211800) is highly warranted.