Intriguingly, while pathogenic variants in the ABCC6 gene are absent in PXE-like β-thalassemia patients, a mouse model of the disease (Hbbth3/+) showed a liver-specific downregulation of Abcc6 expression, mimicking the genetic ABCC6-deficiency of PXE [50]. This evidence concerns the gene ABCC6 and pseudoxanthoma elasticum (inherited or acquired).