Figure 4 shows the hub genes and the associated regulatory miRNA molecules. The top five miRNAs were described in Table 2. From Table 2, mir-34a-5p, mir-129-2-3p, mir-103a-3p and mir-124-3p were found to be more associated with psoriasis. According to research, miR-34a-5p downregulation increases osteoarthritis cell proliferation while decreasing apoptosis and autophagy [7]. MiR-129-2-3p is engaged in the malfunctioning of diabetic neutrophils. Neutrophil retention kinetics and chronic inflammation may be triggered by miR-129-2-3p regulated genes such as Casp6 and Ccr2 [8]. This evidence concerns the gene CASP6 and osteoarthritis.