For example, nuclear factor I-C (NFIC) was predicted to regulate MCM10, TOP2A, ESCO2, CDKN3 and CEP55; nuclear transcription factor Y, subunit A (NFYA) was found to regulate TOP2A, ESCO2, CDKN3, IL-1β and HMMR. Identifying the expression of key transcription factors is critical for directing psoriasis gene expression and participating in its physiopathological processes. The gene discussed is TOP2A; the disease is psoriasis.