MAPT and Alzheimer disease: Experimental animal models of T2D, such as HFD (high-fat diet) rodents, obese ob/ob mice, obese and diabetic db/db mice, or Zucker rats with leptin resistance, also exhibit AD-like alterations such as an increase in tau phosphorylation, a deficit of neuroplasticity evidenced by an impairment in long-term potentiation, and decreased neurogenesis [126,129,146].