In PCLS collected from COPD donors and submaximally contracted with CCh, BDP/FOR/GLY administered at a 100:6:12.5 concentration ratio induced a supra-additive effect, as resulted from the analysis of interaction via Bliss model; according to the Loewe and HSA models, a significant (p < 0.05) synergistic bronchorelaxant response resulted when BDP/FOR administered at concentrations of 1.06–31.8 ng/mL was combined with GLY at concentrations of 0.125–3.75 ng/mL. Here, ALB is linked to chronic obstructive pulmonary disease.