In two ex vivo studies [22,25], overnight treatment with BDP 0.3–300 nM in medium bronchi and with BDP 1 nM–30 μM in PCLS did not significantly (p > 0.05) reduce the histaminergic contractile tone in non-sensitized tissues [22], in passively sensitized tissues incubated with serum from atopic asthma patients (total IgE 1000 U/mL) [22,25], and in airways collected from COPD donors and submaximally contracted by CCh [25]. The gene discussed is IGHE; the disease is chronic obstructive pulmonary disease.