KDR and breast cancer: Ma et al. investigated the effect of berberine on BC cell growth and migration, and reported downregulated matrix metalloproteinase (MMP)-2/-9 expression, diminished vascular endothelial growth factor receptor 2 (VEGFR2) phosphorylation, as well as ephrin-B2 and its PDZ binding proteins decrease, leading to reduced ZR-75-30 BC cell proliferation and migration [35].